Human CellExp™ Latent Activin A / INHBA,human recombinant | P1078

Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion. Activins are nonglycosylated homodimers or heterodimers of various subunits (A, B, C, and E in mammals), while Inhibins are heterodimers of a unique subunit and one of the subunits. Activin A is a widely expressed homodimer of two A chains. The A subunit can also heterodimerize with a B or C subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human A chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat A. Activin is produced in the gonads, pituitary gland, placenta, and other organs. The bioactivity of Activin A is regulated by a variety of mechanisms. In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization; Activin is strongly expressed in wounded skin, and overexpression of activin in epidermis of transgenic mice improves wound healing and enhances scar formation; Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and especially kidney. Activin A increased the expression level of type-I collagen suggesting that activin A acts as a potent activator of fibroblasts; Lack of activin during development results in neural developmental defects.

P1078 | Human CellExp Latent Activin A / INHBA human recombinant DataSheet

Biomolecule/Target: INHBA

Synonyms: Activin A, INHBA, Inhibin beta A chain

Alternates names: Angiostatin K1-4, Angiostatin Kringles 1-4, plasminogen

Taglines: >90% Pure, Human cell expressed Activin A/ INHIBA

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source: Human

Accession #:

Recombinant: Yes

Source: Human Plasma

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1 EU/g

Activity (Specifications/test method): N/A

Biological activity:

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 50.0 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: N/A

Amino acid sequence: N/A