Human CellExp™ LEPR/CD295, human recombinant | 7497

Leptin receptor (LEPR), also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.

7497 | Human CellExp LEPR/CD295 human recombinant DataSheet

Biomolecule/Target: LEPR/CD295

Synonyms: LEPR, CD295, DKFZp686B1731, LEP-R, OB-R, OBR, Leptin receptor

Alternates names: Angiostatin K1-4, Angiostatin Kringles 1-4, plasminogen

Taglines: Mediates the biological function of the adipocyte-specific hormone Leptin

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source: Human

Accession #: P00747

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: The activity is assayed on anti-proliferation and anti-migration of endothelial cells in vitro and anti-angiogenesis in vivo. The specific activity of anti-migration of endothelial cells in vitro is 0.55×10 Units/mg.

Results: 0.55×10 Units/mg.

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 30.0 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution Instructions: Reconstitute in sterile distilled HO or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.

Amino acid sequence: N/A