Human CellExp™ MAG / Siglec-4a, Fc Tag, Human Recombinant | P1481

Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides.

P1481 | Human CellExp™ MAG / Siglec-4a, Fc Tag, Human Recombinant DataSheet

Biomolecule/Target :

Synonyms: MAG, Siglec-4a, GMA, S-MAG

Alternates names: MAG, Siglec-4a, GMA, S-MAG

Taglines: Adhesion molecule that mediates interactions between myelinating cells and neurons

NCBI Gene ID #: 4099

NCBI Gene Symbol: MAG

Gene Source: Human

Accession #: P20916-1

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE: >95%

Assay: SDS-PAGE

Purity:

Assay #2:

Endotoxin Level: Less than 1.0 EU per ug by the LAL method.

Activity (Specifications/test method):

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 81.1 kDa. The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration:

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Amino acid sequence: Gly 20 - Pro 516

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans