Human CellExp™ Nectin-2 / CD112, Human Recombinant | P1371

Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

P1371 | Human CellExp Nectin-2 / CD112 Human Recombinant DataSheet

Biomolecule/Target: NECTIN2

Synonyms: CD112, Nectin-2, PVRL2

Alternates names: SUMO-2, Ubiquitin-like protein SMT3B, SMT3 homolog 2, Sentrin-2, HSMT3, SUMO-3, Sentrin2, SUMO2, SMT3H2, MGC117191.

Taglines: Modulator of T-cell signaling.

NCBI Gene ID #: 6613

NCBI Gene Symbol: SUMO2

Gene Source: Human

Accession #: P61956

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per 1 g of protein

Activity (Specifications/test method): N/A

Biological activity: Typical in vitro concentrations for conjgate formation is 10-50 µM depending on conditions.

Results: 10-50 µM

Binding Capacity: Immobilized Human PVRIG, Mouse IgG2a Fc Tag, low endotoxin at 2 g/mL (100 L/well) can bind Human Nectin-2, His Tag with a linear range of 0.078-0.625 g/mL

Unit Definition: N/A

Molecular Weight: 11.6 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH5.0. Normally trehalose is added as protectant before lyophilization.

Reconstitution Instructions: N/A

Amino acid sequence: N/A