Human CellExp™ PDGF-CC, Human Recombinant | P1526

PDGF-CC is a member of the platelet-derived growth factor (PDGF) family, which was originally identified as a serum growth factor for fibroblasts, smooth muscle cells and glia cells. The PDGF family consists of proteins derived from four genes (PDGF-A, -B, -C, and -D) that form four disulfide-linked homodimers (PDGF-AA, -BB, -CC, and -DD) and one heterodimer (PDGF-AB). These proteins regulate diverse cellular functions by binding to and inducing the homo- or hetero-dimerization of two receptor tyrosine kinases (PDGF R alpha and R beta). PDGF-CC is expressed in multiple embryonic and adult cell types and tissues. PDGF-CC is involved in pathogenesis of neurologic diseases, cancer and fibrosis. The PDGF-CC ligand has also been shown to be involved in tumor growth by paracrine signaling through PDGFRα in malignant melanoma and cervical carcinoma.

P1526 | Human CellExp™ PDGF-CC, Human Recombinant DataSheet

Biomolecule/Target :

Synonyms: Platelet-derived growth factor C, PDGFCC; PDGF-CC, Fallotein, Spinal cord-derived growth factor, SCDGF, VEGF-E

Alternates names: Platelet-derived growth factor C, PDGFCC; PDGF-CC, Fallotein, Spinal cord-derived growth factor, SCDGF, VEGF-E

Taglines: Potent mitogen for a variety of cell types

NCBI Gene ID #: 56034

NCBI Gene Symbol: PDGFC

Gene Source: Human

Accession #: Q9NRA1

Recombinant: TRUE

Source: HEK 293 cells

Purity by SDS-PAGE: >95%

Assay: SDS - PAGE

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Unit Definition:

Molecular Weight: 16 kDa (6×His tag at the C-terminus)

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Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.

Amino acid sequence: aa Val 235 – Gly 345

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans