Human CellExp™ PDGF R alpha / PDGFRA, Human Recombinant | P1460

PDGFRA(platelet-derived growth factor receptor A), also termed PDGFRα(platelet-derived growth factor receptor α), is a receptor located on the surface of a wide range of cell types. This receptor binds to certain isoforms of platelet-derived growth factors (PDGFs) and thereby becomes active in stimulating cell signaling pathways that elicit responses such as cellular growth and differentiation. The receptor is critical for the development of certain tissues and organs during embryogenesis and for the maintenance of these tissues and organs, particularly hematologic tissues, throughout life. Mutations in the gene which codes for PDGFRA, are associated with an array of clinically significant neoplasms.

P1460 | Human CellExp™ PDGF R alpha / PDGFRA, Human Recombinant DataSheet

Biomolecule/Target :

Synonyms: PDGFRA, CD140A, PDGFR2, RHEPDGFRA, MGC74795

Alternates names: PDGFRA, CD140A, PDGFR2, RHEPDGFRA, MGC74795

Taglines: Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells.

NCBI Gene ID #: 5156

NCBI Gene Symbol: P16234

Gene Source: Human

Accession #: P16234-1

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE: >95%

Assay: SDS-PAGE.

Purity:

Assay #2:

Endotoxin Level: Less than 1.0 EU per ug by the LAL method.

Activity (Specifications/test method):

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 58.4 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration:

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Amino acid sequence: Gln 24 - Ala 528

Handling: Centrifuge the vial prior to opening.

Usage: