Human CellExp™ PECAM-1, Human Recombinant | 7184

PECAM is transmembrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. It is highly expressed at endothelial cell junctions, and also expressed in platelets and in most leukocyte sub-types. The primary function of PECAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. PECAM-1 has been implicated in the pathogenesis of various inflammation related disorders, including thrombosis, multiple sclerosis (MS), and rheumatoid arthritis. The human PECAM-1 gene codes for a 738 amino acid transmembrane glycoprotein containing a 118 amino acid cytoplasmic domain, a 19 amino acid transmembrane domain, and a 574 amino acid extracellular domain. Recombinant human PECAM-1 is a 572 amino acid glycoprotein comprising the extracellular domain of PECAM-1. Monomeric glycosylated PECAM-1 migrates at an apparent molecular weight of approximately 80.0-95.0 kDa by SDS-PAGE analysis under reducing conditions.

7184 | Human CellExp PECAM-1 Human Recombinant DataSheet

Biomolecule/Target: PECAM1

Synonyms: Platelet endothelial cell adhesion molecule, CD31 antigen, EndoCAM

Alternates names: GHR, GHBP, GH receptor, Somatotropin receptor, Serum-binding protein

Taglines: Mediates leukocyte-endothelial cell adhesion and signal transduction

NCBI Gene ID #: 2690

NCBI Gene Symbol: GHR

Gene Source: Human

Accession #: P10912

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).

Activity (Specifications/test method): N/A

Biological activity: GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 30.3 kDa (19-256 aa + N-terminal poly-his tag)

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium phosphate, pH 7.5

Reconstitution Instructions: Reconstitute in sterile dHO not less than 100 g/ml. This solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A