Human CellExp™ Progranulin, Human Recombinant | 4738

Progranulin, also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6.0 kDa peptides and named granulin A (epithelin 1), granulin B (epithelin 2), granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Progranulin Human Recombinant fused to FLAG at C-terminus produced in HEK is a single, glycosylated, polypeptide chain containing 593 amino acids and having a molecular mass of 88.0 kDa. The Progranulin is purified by standard chromatographic techniques.

4738 | Human CellExp Progranulin Human Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Acrogranin, Paragranulin, Granulin-1

Alternates names: C49A, FISP, MDA7, ST16, IL-24, IL10B, Mob-5, MDA-7, Suppression of tumorigenicity 16 protein, Melanoma differentiation-associated gene 7 protein.

Taglines: Regulator of cell growth, wound healing, and tumorigenesis

NCBI Gene ID #: 11009

NCBI Gene Symbol: IL24

Gene Source: Human

Accession #: Q13007

Recombinant: Yes

Source: Sacharomyces cerevisiae

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: 90%

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Measured by its ability to bind to the cell receptor of Capan-1 cells line resulted in Stat-3 activation. The ED for this effect is typically 1.0 ng/ml.

Results: 1.0 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 19.5 kDa

Concentration: 0.5 mg/ml

Appearance: Liquid

Physical form description: Sterile filtered clear solution in PBS

Reconstitution Instructions: Reconstitute in sterile dHO not less than 100 g/ml. This solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A