Human CellExp™ Progranulin, Rat Recombinant | 4735

Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. Rat Recombinant Progranulin fused to FLAG® at C-terminus produced in HEK is a single, glycosylated, polypeptide chain purified by standard chromatographic techniques, containing 602 amino acids and having a molecular mass of ~65.0 kDa.

4735 | Human CellExp Progranulin Rat Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Proepithelin; PEPI; PC Cell-derived Growth Factor

Alternates names: Interleukin-28A, IL-28A, IFN-Lambda 2, Interferon-Lambda 2, Cytokine ZCYTO20, IL28A, IFNL2, ZCYTO20, Cytokine receptor family 2 member 12.

Taglines: Regulator of cell growth, wound healing, and tumorigenesis

NCBI Gene ID #: 282616

NCBI Gene Symbol: IL28

Gene Source: Human

Accession #: Q8IZJ0

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 85%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: <0.1 EU/g purified protein

Activity (Specifications/test method): N/A

Biological activity: Test in process

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 19.6 kDa

Concentration: 0.3 mg/ml

Appearance: Lyophilized protein

Physical form description: Lyophilized from 0.2 µm-filtered solution in PBS.

Reconstitution Instructions: Reconstitute in sterile dHO not less than 100 g/ml. This solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A