Human CellExp™ Progranulin (untagged), Human Recombinant | 4737

Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

4737 | Human CellExp Progranulin untagged Human Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Recombinant Human Progranulin (Untagged)

Alternates names: GHR, GHBP, GH receptor, Somatotropin receptor, Serum-binding protein

Taglines: Regulator of cell growth, wound healing, and inflammation linked to tumorigenesis

NCBI Gene ID #: 2690

NCBI Gene Symbol: GHR

Gene Source: Human

Accession #: P10912

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <0.1 EU/µg purified protein

Activity (Specifications/test method): N/A

Biological activity: GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 30.3 kDa (19-256 aa + N-terminal poly-his tag)

Concentration: 1 mg/ml

Appearance: Lyophilized protein

Physical form description: Lyophilized from PBS, pH 7.4

Reconstitution Instructions: Reconstitute in sterile dHO not less than 100 g/ml. This solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A