Human CellExp™ Progranulin (untagged), Rat Recombinant | 4736

Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

4736 | Human CellExp Progranulin untagged Rat Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Recombinant Rat Progranulin (Untagged)

Alternates names: C49A, FISP, MDA7, ST16, IL-24, IL10B, Mob-5, MDA-7, Suppression of tumorigenicity 16 protein, Melanoma differentiation-associated gene 7 protein.

Taglines: Regulator of cell growth, wound healing, and tumorigenesis

NCBI Gene ID #: 11009

NCBI Gene Symbol: IL24

Gene Source: Human

Accession #: Q13007

Recombinant: Yes

Source: Sacharomyces cerevisiae

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <0.1 EU/µg purified protein

Activity (Specifications/test method): N/A

Biological activity: Measured by its ability to bind to the cell receptor of Capan-1 cells line resulted in Stat-3 activation. The ED for this effect is typically 1.0 ng/ml.

Results: 1.0 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 19.5 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized from 0.2 m-filtered solution in PBS, pH 7.2.

Reconstitution Instructions: Reconstitute in sterile dHO not less than 100 g/ml. This solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A