Human CellExp™ RBP4, human recombinant | 7563

Retinol binding protein 4 (RBP4; RBP) is a 21 kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity, and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function.

7563 | Human CellExp RBP4 human recombinant DataSheet

Biomolecule/Target: RBP4

Synonyms: Retinol Binding Protein 4, Plasma retinol-binding protein, PRBP, RBP

Alternates names: Interleukin 31, IL31, IL-31

Taglines: The primary transporter of retinol (vitamin A) to tissues and an adipokine linking GLUT4 suppression in adipose tissue to insulin

NCBI Gene ID #: 386653

NCBI Gene Symbol: IL31

Gene Source: Human

Accession #: Q6EBC2

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <0.1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: The ED50 was determined by its ability to activate STAT following receptor ligand interaction and found to be <5 ng/ml, corresponding to a specific activity of 200,000 units.

Results: <5 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 15.8 kDa

Concentration: N/A

Appearance: Liquid

Physical form description: 0.5 mg/ml of 0.2 m-filtered solution in PBS, pH 7.2.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile HO to a concentration 100 µg/ml. This solution can then be diluted into other aqueous buffers.

Amino acid sequence: SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALK SLTSGAQQATT