Human CellExp™ SARS-CoV-2 Spike RBD (N501Y), Recombinant | P1644

SARS-CoV-2 Spike protein is a large type I transmembrane protein composed of S1 subunit and S2 subunit. During viral infection, the receptor-binding domain (RBD) of the S1 subunit is responsible for the recognition and binding of host receptor ACE2, while the S2 subunit mediates viral cell membrane fusion. The SARS-CoV-2-S1-RBD/ACE2 interaction mediates viral entry into the target cells. The N501Y mutation in the receptor-binding domain (RBD) of SARS-CoV-2 variants increases binding affinity to ACE2.

P1644 | Human CellExp™ SARS-CoV-2 Spike RBD (N501Y), Recombinant DataSheet

Biomolecule/Target :

Synonyms: COVID-19 Spike RBD protein (N501Y); 2019-nCoV Spike RBD protein (N501Y); SARS-CoV-2 Mutant (N501Y); SARS-CoV-2 (N501Y) mutant protein

Alternates names: COVID-19 Spike RBD protein (N501Y); 2019-nCoV Spike RBD protein (N501Y); SARS-CoV-2 Mutant (N501Y); SARS-CoV-2 (N501Y) mutant protein

Taglines: Spike RBD (N501Y) mutant increases binding affinity to ACE2

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source: Coronavirus

Accession #: QHD43416.1

Recombinant: 1

Source: Human cells

Purity by SDS-PAGE: ≥ 95% by SDS-PAGE

Assay:

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Unit Definition:

Molecular Weight: The predicted molecular weight is 26 kDa. The protein migrates as a 33-36 kDa band under reducing conditions

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Appearance: Liquid

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Reconstitution Instructions:

Amino acid sequence: The target protein is expressed with the sequence Arg319-Ser541(N501Y) of SARS-CoV-2 Spike RBD protein fused with a 6xHis tag at the C-terminus.

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans