Human CellExp™ TIGIT, Fc Tag, Mouse Recombinant | P1213

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3), which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

P1213 | Human CellExp TIGIT Fc Tag Mouse Recombinant DataSheet

Biomolecule/Target: Tigit

Synonyms: TIGIT, VSIG9, VSTM3

Alternates names: CFP, Cyan Fluorescent Protein

Taglines: >95% Pure, Human cell expressed TIGIT

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source:

Accession #:

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/g

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: Immobilized Mouse TIGIT, Fc Tag at 5g/mL (100 L/well) can bind Human Nectin-2, His Tag with a linear range of 2.5-20 g/mL.

Unit Definition: N/A

Molecular Weight: 31.3 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in 50 mM Tris, 100 mM Glycine, pH 7.5. Normally trehalose is added as protectant before lyophilization.

Reconstitution Instructions: Reconstitute with dHO to 1 mg/ml

Amino acid sequence: N/A