Human CellExp™ Tim-3, (Fc-Tag Mouse), Mouse Recombinant | P1360

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade

P1360 | Human CellExp Tim-3 Fc-Tag Mouse Mouse Recombinant DataSheet

Biomolecule/Target: Tim-3

Synonyms: TIM3; TIMD3; Hepatitis A Virus Cellular Receptor 2; HAVcr-2; T Cell Immunoglobulin and Mucin Domain-containing Protein 3, HAVCR2

Alternates names: RFP, Red Fluorescent Protein

Taglines: Mediate phagocytosis of apoptotic cells and inhibit aggressive Th1-mediated auto- and alloimmune responses.

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Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <5 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: Immobilized recombinant human Galectin-9 at 500 ng/ml can bind Tim-3 mouse recombinant with an apparent KD <10nM.

Unit Definition: N/A

Molecular Weight: 27.6 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.2 m-filtered solution in PBS

Reconstitution Instructions: Reconstitute with dHO to 1 mg/ml

Amino acid sequence: N/A