Human CellExp™ VSIG4, human recombinant | P1018

VSIG4 (V-set and immunoglobulin domain containing 4), as known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation.

P1018 | Human CellExp VSIG4 human recombinant DataSheet

Biomolecule/Target: VSIG4

Synonyms: V-set and immunoglobulin domain containing 4; Z39Ig; CRIg

Alternates names: Peptidylprolyl isomerase (cyclophilin)-like 1, Rotamase, CGI-124, CYPL1, hCyPX, PPIase.

Taglines: V-set and immunoglobulin domain-containing protein 4

NCBI Gene ID #: 51645

NCBI Gene Symbol: PPIL1

Gene Source: Human

Accession #: Q9Y3C6

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 0.06 EU/mg

Activity (Specifications/test method): N/A

Biological activity: Specific activity is > 300 nmoles/min/mg.

Results:

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 19.3 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.2m-filtered solution in PBS.

Reconstitution Instructions: N/A

Amino acid sequence: MAAIPPDSWQ PPNVYLETSM GIIVLELYWK HAPKTCKNFA ELARRGYYNG TKFHRIIKDF MIQGGDPTGT GRGGASIYGK QFEDELHPDL KFTGAGILAM ANAGPDTNGS QFFVTLAPTQ WLDGKHTIFG RVCQGIGMVN RVGMVETNSQ DRPVDDVKII KAYPSGLEHH HHHH