Human CellExp™ VTCN1, human recombinant | 7412

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

7412 | Human CellExp VTCN1 human recombinant DataSheet

Biomolecule/Target: VTCN1

Synonyms: B7-H4, VTCN1, B7S1, B7h.5

Alternates names: MTRX, TRX2, MT-TRX

Taglines: Negatively regulates T-cell-mediated immune response and is involved in promoting epithelial cell transformation

NCBI Gene ID #: 25828

NCBI Gene Symbol: TXN2

Gene Source: Human

Accession #: Q99757

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: Specific activity is 3-4 A650/min/mg.

Results:

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 11 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: N/A

Amino acid sequence: MTTFNIQDGP DFQDRVVNSE TPVVVDFHAQ WCGPCKILGP RLEKMVAKQH GKVVMAKVDI DDHTDLAIEY EVSAVPTVLA MKNGDVVDKF VGIKDEDQLE AFLKKLIG