Human CXCL10 protein | PRP100185

Human CXCL10 protein | PRP100185 | Gentaur UK, US & Europe Distribution

Product Category: Cytology

Application: Cytokines

Product Type: Cytokines

Sequence: Amino acid sequence derived from mature form of human CXCL10 (Q9UBH0) (Val22-Pro98) was expressed, with a N-terminal Met.

Activity: N/A

protein Lenght: The recombinant human CXCL10 consists of 78 amino acids and predicts a molecular mass of 8.8 KDa. It migrates as an approximately 9 KDa band in SDS-PAGE under reducing conditions.

Preparation: E. coli

Purity: > 90 % as determined by SDS-PAGE

Formulation: Lyophilized from sterile PBS

Kit Component: N/A

Features & Benefits : N/A

Molecular Weight: 8.8 kDa

Usage Note: Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human CXCL10 protein in sterile ddH2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Storage Conditions: Lyophilized Human CXCL10 proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.55% HSA or BSA) . Please prevent freeze-thaw cycles.

Shipping: The product is shipped at ambient temperature.

Background: CXCL10, also known as crg-2, is a chemokine of the CXC subfamily and ligand for the receptor CXCR3. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL10 has a three-dimensional crystal structure. Its signaling is mediated by the g protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. It is chemotactic for monocytes and T-lymphocytes. CXCL10 can be secreted by several cell types in response to IFN-γ. Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1 or 4 who do not achieve a sustained viral response (SVR) after completion of antiviral therapy.

Alternative Names: C7; crg-2; gIP-10; IFI10; INP10; IP-10; mob-1; SCYB10; Interleukin-36 receptor antagonist protein; CXCL10

Search Names: C7; crg-2; gIP-10; IFI10; INP10; IP-10; mob-1; SCYB10; Interleukin-36 receptor antagonist protein; CXCL10

Tag: CXCL10