Human IFN-α2 protein | PRP100327

Human IFN-α2 protein | PRP100327 | Gentaur UK, US & Europe Distribution

Product Category: Cytology

Application: Cytokines

Product Type: Cytokines

Sequence: Amino acid sequence derived from human IFNA2 (NP_000596.2) (Cys24-Glu188) was expressed.

Activity: Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV) . The EC50 for this effect is typically 0.6-4.2pg/mL.

protein Lenght: The recombinant human IFNA2 consists 165 amino acids and predicts a molecular mass of 19.3 kDa.

Preparation: Yeast

Purity: > 95 % as determined by SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.

Kit Component: N/A

Features & Benefits : N/A

Molecular Weight: 19.3 kDa

Usage Note: Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IFN alpha 2 protein in sterile ddH2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Storage Conditions: Lyophilized Human IFN-α2 proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.78% HSA or BSA) . Please prevent freeze-thaw cycles.

Shipping: The product is shipped at ambient temperature.

Background: Human interferon α-2 (IFNα2) is a cytokine belonging to the family of type I IFNs. IFNα2 is a protein secreted by cells infected by a virus and acting on other cells to inhibit viral infection. The first description of IFNs as a cellular agent interfering with viral replication was made by Alick Isaacs and Jean Lindenmann in 1957. The history of this finding was recently reviewed. There are 3 types of IFNs: Interferon type I, Interferon type II and Interferon type III. The type II IFN, also called IFNγ, is produced by specific cells of the immune system. Unlike type I and type III IFNs, IFNγ has only a modest role in directly restricting viral infections. Type I and type III IFNs act similarly. However, the action of type III IFNs, also known as IFNλ, is limited to epithelial cells while type I IFNs act on all body's cells.

Alternative Names: IFN-alphaA; IFNA; IFNA2B; IFNAB; INFA2; Interferon alpha 2; Interferon alpha-2; IFNA2

Search Names: IFN-alphaA; IFNA; IFNA2B; IFNAB; INFA2; Interferon alpha 2; Interferon alpha-2; IFNA2

Tag: IFN-α2