Human Insulin Fibrillation Inhibitor Screening Kit (Fluorometric) | K2104-100

Human Insulin Fibrillation Inhibitor Screening Kit (Fluorometric) | K2104-100

Description: Human insulin consists of 51 amino acids, with a molecular mass of 5.81 kDa. It contains two peptide chains (A & B), which are linked by two disulfide bonds. Human insulin is widely used as a drug for treating diabetes patients. However, under certain conditions, human insulin aggregates into insoluble fibrils via fibrillogenesis, which leads to complications including reduced insulin potency, occlusion of insulin delivery devices, potentially increased immunological potential etc. Therefore screening of potential Inhibitors of human insulin fibrillation is critical for preventing insulin aggregation and developing potential therapeutics. In ’s Human Insulin Fibrillation Inhibitor Screening kit, insulin fibrillation is induced by low pH and high temperature. Fibrillation Assay Probe then binds to the beta sheets of the insoluble fibrils to generate a strong fluorescence signal meased at Ex/Em = 440/500 nm. But in the presence of an insulin fibrillation inhibitor, fibrillation is inhibited thereby reducing the fluorescence signal. The assay is simple, reliable and is high-throughput adaptable.

Alternate Name: Insulin Fibrillation Inhibitor Screening Kit Human Insulin Fibrillation Inhibitor Screening Kit Insulin Fibrillation Inhibitor Screening Kit (Fluorometric)

Tag Line: For screening potential inhibitors of human insulin fibrillation

Summary: A simple and reliable, fluorometric assay for screening potential inhibitors of human insulin fibrillation.

Detection Method: Fluorescence (Ex/Em = 440/500 nm)

Sample Type:

Species Reactivity: Human

Applications: For screening potential inhibitors of human insulin fibrillation

Features & Benefits: The assay is simple, reliable and is high-throughput adaptable