Human Recombinant AKR1C3 | 6337

Aldo-keto reductase family 1 member C3 in humans is encoded by the AKR1C3 gene. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha, 11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation.

6337 | Human Recombinant AKR1C3 DataSheet

Biomolecule/Target: N/A

Synonyms: Human Recombinant AKR1C3

Alternates names: Peptidyl-prolyl cis-trans isomerase-like 3 isoform PPIL3b, CYPJ.

Taglines: Involved in in the detoxification of aldehydes and ketones

NCBI Gene ID #: 53938

NCBI Gene Symbol: PPIL3

Gene Source: Human

Accession #: Q9H2H8

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per 1 g of protein (determined by LAL method).

Activity (Specifications/test method): N/A

Biological activity: Specific activity is > 280 nmoles/min/mg

Results:

Binding Capacity: N/A

Unit Definition: One unit is the amount of enzyme that reduces 1.0 µmole of NADP+ to NADPH per min. at pH 7.4 at 37°C.

Molecular Weight: 20.3 kDa

Concentration: 1 mg/ml

Appearance: Liquid

Physical form description: 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.

Reconstitution Instructions: N/A

Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MSVTLHTDVG DIKIEVFCER TPKTCENFLA LCASNYYNGC IFHRNIKGFM VQTGDPTGTG RGGNSIWGKK FEDEYSEYLK HNVRGVVSMA NNGPNTNGSQ FFITYGKQPH LDMKYTVFGK VIDGLETLDE LEKLPVNEKT YRPLNDVHIK DITIHANPFA Q