Human Recombinant Cyclophilin D | 6312

Cyclophilin D is a member of peptidyl-propyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins and thus their formation. Cyclophilin D is also a mitochondrial matrix protein, which plays a decisive role in mitochondrial permeability transition. It can bind to the immunosuppressant cyclosporine A and its overexpression suppresses the apoptosis in cancer cells.

6312 | Human Recombinant Cyclophilin D DataSheet

Biomolecule/Target: N/A

Synonyms: Human Recombinant Cyclophilin D

Alternates names: Peptidylprolyl isomerase D, PPID, CYPD, CYP-40

Taglines: An immunophilin family protein catalyzing the isomerization of peptide bonds

NCBI Gene ID #: 332

NCBI Gene Symbol: BIRC5

Gene Source: Human

Accession #: O15392

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Specific activity is > 210 nmoles/min/mg

Results: N/A

Binding Capacity: N/A

Unit Definition: Specific activity is defined as the amount of enzyme that cleaves 1 µmole of Suc-AAFP-pNA per minute at 25°C in Tris HCl pH 8.0 using chymotrypsin.

Molecular Weight: 42.9 kDa

Concentration: 1 mg/ml

Appearance: Liquid

Physical form description: 1 mg/ml solution in PBS (pH 7.4) containing 10% glycerol.

Reconstitution Instructions: N/A

Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGelKEGDDG GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL