Human Recombinant Glyoxalase I | 6389

GLO1 is involved in the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutathione. GLO1 is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. GLO1 enzyme is abundantly expressed and present in numerous tumor cell lines, in which its concentration is often upregulated ubiquitously. GLO1 is a major susceptible gene for autism in an ethnic Chinese population from Taiwan. GLO1 might be involved in the pathophysiology of mood disorders. GLO1 plays a role in the pathophysiology of mood disorders. Overexpression of GLO1 is associated with kidney tumor.

6389 | Human Recombinant Glyoxalase I DataSheet

Biomolecule/Target: N/A

Synonyms: Human Recombinant Glyoxalase I

Alternates names: Lactoylglutathione lyase, Glx 1, GLO-1 Methylglyoxalase, Aldoketomutase

Taglines: Involved in the pathophysiology of mood disorders

NCBI Gene ID #: 16168

NCBI Gene Symbol: IL15

Gene Source: Human

Accession #: P48346

Recombinant: Yes

Source: E. Coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Specific activity: >0.4 units/mg.

Results: >0.4 units/mg

Binding Capacity: N/A

Unit Definition: One unit will form 1.0 µmol of S-lactoylglutathione from methylglyoxal and reduced glutathione per minute at pH 7.5, at 25°C. Specific activity was expressed in units/mg of protein.

Molecular Weight: 20.7 kDa (184 aa, 1-184 aa)

Concentration: 1 mg/ml

Appearance: Liquid

Physical form description: 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.

Reconstitution Instructions: N/A

Amino acid sequence: MAEPQPPSGG LTDEAALSCC SDADPSTKDF LLQQTMLRVK DPKKSLDFYT RVLGMTLIQK CDFPIMKFSL YFLAYEDKND IPKEKDEKIA WALSRKATLE LTHNWGTEDD ETQSYHNGNS DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKM ATLM