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Human Recombinant GSTM 2 | 6350

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SKU:
26-6350-GEN
Availability:
Usually shipped in 5 working days
NULL797.00

Description

Glutathione S-transferase Mu 2 (GSTM2) belongs to the Glutathione S-Transferase (GST) family of proteins. There are 8 families of GST proteins: alpha, kappa, mu, omega, pi, sigma, theta and zeta, each of which is composed of proteins that have various functions throughout the cell. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are structured in a gene cluster on chromosome 1p13.3 and are proven to be highly polymorphic. These genetic variants can change an individual's susceptibility to carcinogens and toxins as well as have an effect on the toxicity and efficacy of several drugs.

6350 | Human Recombinant GSTM 2 DataSheet

Biomolecule/Target: N/A

Synonyms: Human Recombinant GSTM 2

Alternates names: Glutathione S-transferase Mu 2, GST4, GSTM, GSTM2-2, GTHMUS.

Taglines: Plays a role in detoxification of electrophilic compounds

NCBI Gene ID #: 25670

NCBI Gene Symbol: IL15

Gene Source: Human

Accession #: P97604

Recombinant: Yes

Source: E. Coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Specific activity is < 25 units/mg.

Results: N/A

Binding Capacity: N/A

Unit Definition: Specific activity is defined as the amount of enzyme that conjugates 1.0 µ mole of 1-chloro-2, 4-dinitrobenzene (CDNB) with reduced glutathione per minute at pH 6.5 at 25°C.

Molecular Weight: 27.9 kDa

Concentration: 0.5 mg/ml

Appearance: Liquid

Physical form description: 0.5 mg/ml solution in 20 mM Tris HCl (pH 8.0) containing 10% glycerol, 0.1 M NaCl and 1 mM DTT.

Reconstitution Instructions: N/A

Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MPMTLGYWNI RGLAHSIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL PYLIDGTHKI TQSNAILRYI ARKHNLCGES EKEQIREDIL ENQFMDSRMQ LAKLCYDPDF EKLKPEYLQA LPEMLKLYSQ FLGKQPWFLG DKITFVDFIA YDVLERNQVF EPSCLDAFPN LKDFISRFEG LEKISAYMKS SRFLPRPVFT KMAVWGNK

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Additional Information

Storage:
-20°C
Shipping:
Gel Pack
Shelf Life:
12 months
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