HUMAN-RIN1 (Y36) Antibody [APR04704G]

HUMAN-RIN1 (Y36) Antibody [APR04704G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 20-70 amino acids from human.

Cellular Localisation: Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated

Molecular Weight: 84099

Clone: Polyclonal

Gene Name: RIN1

Gene ID: 9610

Function: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Summary: Tissue Location: Expressed in all tissues examined with high levels in brain, placenta and pancreas.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Ras and Rab interactor 1, Ras inhibitor JC99, Ras interaction/interference protein 1, RIN1