Human sRANKL protein | PRP1031

Human sRANKL protein | PRP1031 | Gentaur UK, US & Europe Distribution

Product Category: Cytology

Application: Cytokines

Product Type: Cytokines

Sequence: Amino acid sequence derived from Human sRANKL (O14788) (Glu143-Asp317) was expressed.

Activity: N/A

protein Lenght: The recombinant human sRANKL consists of 175 amino acids and migrates with an apparent molecular mass of 19 kDa as estimated in SDS-PAGE under reducing conditions.

Preparation: E. coli

Purity: ≥ 98 % as determined by SDS-PAGE

Formulation: Lyophilized from sterile 20 mM Tris, 150 mM NaCl pH 8.0.

Kit Component: N/A

Features & Benefits : N/A

Molecular Weight: 19 kDa

Usage Note: Always centrifuge tubes before opening . It is recommended to centrifuge at 12000 rpm for 1 minute.Then reconstitute the lyophilized Human sRANKL protein using the buffer we provided not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Storage Conditions: Lyophilized Human sRANKL proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.132% HSA or BSA) . Please prevent freeze-thaw cycles.

Shipping: Gel pack with blue ice.

Background: Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. TNFSF11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation.

Alternative Names: soluble Receptor Activator of NF-κB Ligand, TNFSF11, TRANCE (TNF-related activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor)

Search Names: soluble Receptor Activator of NF-κB Ligand, TNFSF11, TRANCE (TNF-related activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor)

Tag: sRANKL