Hypericin | 2526

Isolated from Hypericum perforatum, St. John’s Wort. Hypericin has been shown to display antiviral and antiretroviral activity. A potent and selective inhibitor of protein kinase C (IC₅₀ = 3.4 µM). Also known to inhibit Casein Kinase II (CKII), MAP Kinase, Insulin R, EGFR, PI-3 Kinase. Displays antineoplastic and antitumor actitities. Most activities require light activation. Induces apoptosis in neuroblastoma cells at 1 µM or above (IC₅₀ = 0.1 µM at 29 mW/cm2 (tungsten light)). Used in photodynamic treatment of tumors and has been reported to be cytotoxic to some tumor cell lines when Hypericin is photoactivated.

Hypericin has been shown to display antiviral and antiretroviral activity. A potent and selective inhibitor of protein kinase C (IC₅₀ = 3.4 µM). Also known to inhibit Casein Kinase II (CKII), MAP Kinase, Insulin R, EGFR, PI-3 Kinase. Displays antineoplastic and antitumor actitities. Most activities require light activation. Induces apoptosis in neuroblastoma cells at 1 µM or above (IC₅₀ = 0.1 µM at 29 mW/cm2 (tungsten light)).

2526 | Hypericin DataSheet

Alternate Name/Synonyms: 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione

Appearance: Black solid

Formulation: N/A

CAS Number: 548-04-9

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₁₆O₈

Molecular Weight: 504.45

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~25 mg/ml) or EtOH (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent anticancer and antidepressant agent

MDL Number: MFCD00016683

PubChem CID: 5281051

SMILES: CC1=CC(=C2C3=C1C4=C5C(=C(C=C4C)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O

InChi: InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3

InChi Key: BTXNYTINYBABQR-UHFFFAOYSA-N