ICB1 Antibody (C-term) [APR32753G]

ICB1 Antibody (C-term) [APR32753G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ICB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-641 amino acids from the C-terminal region of human ICB1.

Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:Q91YX0}. Cytoplasm {ECO:0000250|UniProtKB:Q91YX0}

Molecular Weight: 72049

Clone: Polyclonal

Gene Name: THEMIS2 (HGNC:16839)

Gene ID: 9473

Function: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716) . Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity) .

Summary: Tissue Location: Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: FC, WB

Dilution: WB--1:1000 FC--1:10~50

Synonyms: Protein THEMIS2, Induced by contact to basement membrane 1 protein, Protein ICB-1, Thymocyte-expressed molecule involved in selection protein 2, THEMIS2, C1orf38, ICB1