IER5 Antibody (Center) [APR31525G]

IER5 Antibody (Center) [APR31525G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This IER5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-149 amino acids from the Central region of human IER5.

Cellular Localisation: Nucleus. Cytoplasm. Note=Predominantly cytoplasmic (PubMed:25816751) . Translocated in the nucleus during heat shock (PubMed:25816751) .

Molecular Weight: 33704

Clone: Polyclonal

Gene Name: IER5

Gene ID: 51278

Function: Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627) . Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1- dependent manner (PubMed:25355627, PubMed:25816751) . Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193) . Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226) . Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226) . Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193) . Associates with chromatin to the CDC25B promoter (PubMed:22132193) .

Summary: Tissue Location: Expressed in acute myeloid leukemia (AML) cells.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Immediate early response gene 5 protein, IER5