IFT57 Antibody (Center) [APR33647G]

IFT57 Antibody (Center) [APR33647G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This IFT57 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 159-193 amino acids from the Central region of human IFT57.

Cellular Localisation: Cytoplasm, cytoskeleton, cilium basal body. Note=Concentrates within the inner segment of cilia

Molecular Weight: 49108

Clone: Polyclonal

Gene Name: IFT57

Gene ID: 55081

Function: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity) . Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'- AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

Summary: Tissue Location: Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level)

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Intraflagellar transport protein 57 homolog, Dermal papilla-derived protein 8, Estrogen-related receptor beta-like protein 1, HIP1-interacting protein, MHS4R2, IFT57, DERP8, ESRRBL1, HIPPI