IITZ-01 | B2378

IITZ-01 is a potent potent lysosomotropic autophagy inhibitor; displays >10-fold potent autophagy inhibition than Chloroquine (Cat. No.1825); enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy. Displays potent anticancer activity.

IITZ-01 is a potent potent lysosomotropic autophagy inhibitor; displays >10-fold potent autophagy inhibition than Chloroquine (Cat. No.1825); enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy. Displays potent anticancer activity.

B2378 | IITZ-01 DataSheet

Alternate Name/Synonyms: N2-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine, IITZ01

Appearance: Crystalline solid

Formulation:

CAS Number: 1807988-47-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₆H₂₃FN₈O

Molecular Weight: 482.51

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent lysosomotropic autophagy inhibitor

MDL Number:

PubChem CID: 135000000

SMILES: C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)F)NC4=CC=C(C=C4)C5=NC6=CC=CC=C6N5

InChi: InChI=1S/C26H23FN8O/c27-18-7-11-20(12-8-18)29-25-32-24(33-26(34-25)35-13-15-36-16-14-35)28-19-9-5-17(6-10-19)23-30-21-3-1-2-4-22(21)31-23/h1-12H,13-16H2,(H,30,31)(H2,28,29,32,33,34)

InChi Key: XGEDDGLPNSLBFE-UHFFFAOYSA-N