Ikaros (C-terminus) monoclonal Antibody | MB0092

Ikaros (C-terminus) monoclonal Antibody | MB0092 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Application: WB IP

Application Range: WB: 1:1000 IP: 1:50~1:200

Background: Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of Ikaros and does not cross-react with related proteins

Molecular Weight: Predicted band size:58KDa Observed band size:58KDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: DNA-binding protein Ikaros; Ikaros family zinc finger protein 1; Lymphoid transcription factor LyF-1; IKZF1; IK1; IKAROS; LYF1; ZNFN1A1

Immunogen: Synthetic peptide, corresponding to the C-terminus of Human Ikaros.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: PI3K AKT signaling,Insulin &Glucose Signaling,