IKK-ε Kinase Inhibitor II | 1811

A benzimidazole analog that acts as a potent and selective inhibitor of IKK-ε kinase (IC₅₀ = 40 nM); displays >125-fold selectivity over IKK-α and IKK-β.

IKK-ε Kinase Inhibitor II is a benzimidazole analog that acts as a potent and selective inhibitor of IKK-ε kinase (IC₅₀ = 40 nM); displays >125-fold selectivity over IKK-α and IKK-β.

1811 | IKK-ε Kinase Inhibitor II DataSheet

Alternate Name/Synonyms: 5-​(5,​6-​dimethoxy-​1H-​benzimidazol-​1-​yl)-​3-​[[2-​(methylsulfonyl)phenyl]methoxy]-​2-​thiophenecarbonitrile

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 862812-98-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₁₉N₃O₅S₂

Molecular Weight: 469.53

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An IKK-ε kinase inhibitor

MDL Number: N/A

PubChem CID: 11626927

SMILES: COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C#N)OCC4=CC=CC=C4S(=O)(=O)C)OC

InChi: InChI=1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)292)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3

InChi Key: LDTAHRLHGHFHKP-UHFFFAOYSA-N