Ikkα polyclonal Antibody | BS90696

Ikkα polyclonal Antibody | BS90696 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, mouse, rat

Application: WB ICC IHC FC

Application Range: WB:1:500 ICC:1:200 IHC:1:200 FC:1:100-1:200

Background: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. It acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Ikkα polyclonal Antibody detects endogenous levels of Ikkα protein.

Molecular Weight: 85 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: I-kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase, IKK1, NFKBIKA, TCF-16, chuk, CHUK1, Conserved Helix Loop Helix Ubiquitous Kinase, Conserved helix loop ubiquitous kinase, Conserved helix-loop-helix ubiquitous kinase, I Kappa B Kinase 1, I Kappa B Kinase Alpha, I-kappa-B kinase 1, I-kappa-B kinase alpha, IkappaB kinase, IkB kinase alpha subunit, IkBKA, IKK 1, IKK A, IKK a kinase, IKK-A, IKK-alpha, IKK1, IKKA, IKKA, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells, Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Inhibitor of nuclear factor kappa-B kinase subunit alpha, NFKBIKA, Nuclear Factor Kappa B Inhibitor Kinase Alpha, Nuclear factor NF kappa B inhibitor kinase alpha, Nuclear factor NF-kappa-B inhibitor kinase alpha, Nuclear factor NFkappaB inhibitor kinase alpha, Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor, TCF-16, TCF16, Transcription factor 16,

Immunogen: peptide

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Peptide affinity purified

Pathway: PI3K AKT signaling,