IL-1 RA, human recombinant | 4263

Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1RA Human Recombinant produced in E.Coli is a non-glycosylated, N-terminal methionyl form of the human naturally-occurring polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton. The IL1RA is purified by proprietary chromatographic techniques.

4263 | IL-1 RA human recombinant DataSheet

Biomolecule/Target: IL-1 RA

Synonyms: IRAP, IL1F3, IL1RA, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, MGC10430

Alternates names: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, PP-1A, PP1alpha, PPP1A.

Taglines: A natural inhibitor of the pro-inflammatory effect of IL1

NCBI Gene ID #: 5499

NCBI Gene Symbol: PPP1CA

Gene Source: Human

Accession #: P62136

Recombinant: Yes

Source: E. Coli

Purity by SDS-PAGEs: 80%

Assay: SDS-PAGE

Purity: 98%

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Specific activity: >3,000 units/mg.

Results: >3,000 units/mg

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 39.7 kDa (350 aa, 1-330 aa + NT His-Tag)

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized without additves

Reconstitution Instructions: N/A

Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MSDSEKLNLD SIIGRLLEVQ GSRPGKNVQL TENEIRGLCL KSREIFLSQP ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVQGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAD KNKGKYGQFS GLNPGGRPIT PPRNSAKAKK