IL-1 RA, murine recombinant | 4264

Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1 ra Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques.

4264 | IL-1 RA murine recombinant DataSheet

Biomolecule/Target: IL-1 RA

Synonyms: IRAP, IL1F3, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, F630041P17Rik,

Alternates names: Dual specificity protein phosphatase 3, VHR.

Taglines: A natural inhibitor of the pro-inflammatory effect of IL1

NCBI Gene ID #: 1845

NCBI Gene Symbol: DUSP3

Gene Source: Human

Accession #: P51452

Recombinant: Yes

Source: E. Coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Specific activity: >1750 units/mg.

Results: >1750 units/mg

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 22.6 kDa (205 aa, 1-185 aa + NT His-Tag)

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized from HO containing NaHCO

Reconstitution Instructions: N/A

Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MSGSFELSVQ DLNDLLSDGS GCYSLPSQPC NEVTPRIYVG NASVAQDIPK LQKLGITHVL NAAEGRSFMH VNTNANFYKD SGITYLGIKA NDTQEFNLSA YFERAADFID QALAQKNGRV LVHCREGYSR SPTLVIAYLM MRQKMDVKSA LSIVRQNREI GPNDGFLAQL CQLNDRLAKE GKLKP