IL-31 Antibody [SB118b] (Biotin) | 99-794

IL-31 Antibody [SB118b] (Biotin) | 99-794 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: E. coli-expressed human IL-31

Research Area: Immunology, Chemokines & Cytokines

Tested Application: E, WB, IHC-P, IHC-WM, ICC, Flow, IP

Application: IL-31 Antibody [SB118b] for use in ELISA assays.

Specificiy: IL-31

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [SB118b]

Isotype: IgG2b

Conjugate: Biotin

Physical State: Liquid

Buffer: Supplied in PBS/NaN3

Concentration: 0.5 mg/mL

Storage Condition: Store vial at 2-8˚C

Alternate Name: Interleukin-31

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Interleukin-31 (IL-31) is a 24 kDa alpha-helical protein and a member of the IL-6 family of cytokines that is preferentially expressed by CD4+ T cells. This cytokine elicits its response by binding to a heterodimeric complex consisting of a gp130-like receptor chain and the oncostatin M receptor subunit. On target cells which include a broad range of immune and non-immune cells, IL-31 binding can induce activation of the Jak/STAT, AKT, and MAPK signaling pathways. Due to the ubiquitous expression of its receptor complex, IL-31 has numerous physiological roles that include regulating hematopoiesis and immune response. Over-expression has been linked to chronic inflammatory states such as dermatitis, pruritus, airway hypersensitivity, and inflammatory bowel disease.