Description
IL-31 monoclonal Antibody | MB9293 | Gentaur UK, US & Europe Distribution
Host: Mouse
Reactivity: Human
Application: WB IHC ICC
Application Range: WB:1:500 ICC:1:100 IHC:1:50-1:200
Background: IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM) . This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD) . Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: IL-31 monoclonal Antibody detects endogenous levels of IL-31 protein.
Molecular Weight: 18 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: IL-31, IL 31, IL-31, IL31, IL31, Interleukin 31, Interleukin-31,
Immunogen: Recombinant full length protein corresponding to human IL18.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein affinity purified.
Pathway:
Related Products
