IL-33 Antibody [SB127j] (Biotin) | 99-800

IL-33 Antibody [SB127j] (Biotin) | 99-800 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: E. coli-expressed human IL-33

Research Area: Innate Immunity

Tested Application: E, WB, IHC-P, IHC-Fr, ICC, EM

Application: IL-33 Antibody [SB127j] for use in ELISA assays.

Specificiy: IL-33

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [SB127j]

Isotype: IgG2a

Conjugate: Biotin

Physical State: Liquid

Buffer: Supplied in PBS/NaN3

Concentration: 0.5 mg/mL

Storage Condition: Store vial at 2-8˚C

Alternate Name: Interleukin-33, IL-1F11, NF-HEV

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Interleukin-33 (IL-33) , also known as NF-HEV, is a 30 kDa protein and a member of the IL-1 family. This pro-inflammatory cytokine is produced by a variety of cells but is primarily expressed by endothelial and smooth muscle cells in the vasculature and airways. IL-33 binds to the ST2 receptor on target cells which results in the activation of multiple signaling pathways including NF-��B and MAP kinases. Studies have shown that IL-33 promotes T helper type 2 (Th2) cell-mediated immune responses and upregulates production of Th2 associated cytokines including IL-4, IL-5, and IL-13. In vivo administration of this cytokine in mice results in eosinophilia and splenomegaly as well as induced severe pathological changes in the lungs, gastrointestinal tract, and other mucosal organs.