IL-36A Antibody | 7505

IL-36A Antibody | 7505 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: IL-36A antibody was raised against an 11 amino acid peptide near the carboxy terminus of human IL-36A.
The immunogen is located within the last 50 amino acids of IL-36A.

Research Area: Immunology

Tested Application: E, WB, IHC-P, IF

Application: IL-36A antibody can be used for detection of IL-36A by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: IL-36A antibody is human specific. IL-36A antibody will not cross-react with IL-36B or IL-36G.

Positive Control 1: Cat. No. 1219 - MCF7 Cell Lysate

Positive Control 2: Cat. No. 10-301 - Human Brain Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 17 kDa
Observed: 16 kDa

Validation: N/A

Isoform: N/A

Purification: IL-36A antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: IL-36A antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: IL-36A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: IL-36A Antibody: FIL1, FIL1E, IL1F6, IL-1F6, IL1 (EPSILON) , FIL1 (EPSILON) , IL1E, Interleukin-36 alpha, FIL1 epsilon, IL-1 epsilon

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: IL-36A is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1) . IL-36A is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP (2) . Like the related proteins IL-36B and IL-36G, IL-36A requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (3) . The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells (4) .