IL17 A/F, Rat Recombinant | 7587

Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17R receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia. In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but, greater activity than the IL-17F homodimer. Human and rat IL-17AF both show activity on mouse cells. Recombinant rat IL-17AF is a non-glycosylated, disulfide-linked heterodimer. It is comprised of one monomeric subunit each of IL-17A and IL-17F, having a total of 269 amino acids and a molecular weight of 30.7 kDa.

7587 | IL17 A/F Rat Recombinant DataSheet

Biomolecule/Target: IL17 A/F

Synonyms: Interleukin 17 A/F, IL-17A, IL-17F, Interleukin 17A, Interleukin 17F

Alternates names: Lactoylglutathione lyase, Glx 1, GLO-1 Methylglyoxalase, Aldoketomutase

Taglines: Induces the production of a variety of chemokines

NCBI Gene ID #: 2739

NCBI Gene Symbol: GLO1

Gene Source: Human

Accession #: Q04760

Recombinant: Yes

Source: E. Coli

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Measured by kinetic LAL analysis and is typically 1 EU/g protein

Activity (Specifications/test method): N/A

Biological activity: Specific activity: >0.4 units/mg.

Results: >0.4 units/mg

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 20.7 kDa (184 aa, 1-184 aa)

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized without any additives.

Reconstitution Instructions: N/A

Amino acid sequence: MAEPQPPSGG LTDEAALSCC SDADPSTKDF LLQQTMLRVK DPKKSLDFYT RVLGMTLIQK CDFPIMKFSL YFLAYEDKND IPKEKDEKIA WALSRKATLE LTHNWGTEDD ETQSYHNGNS DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKM ATLM