IL18R1Antibody (C-term) [APR04727G]

IL18R1Antibody (C-term) [APR04727G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This IL18R1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 527-561 amino acids from the C-terminal region of human IL18R1.

Cellular Localisation: Membrane; Single- pass type I membrane protein

Molecular Weight: 62304

Clone: Polyclonal

Gene Name: IL18R1 (HGNC:5988)

Gene ID: 8809

Function: Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532) . Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850) . Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity) .

Summary: Tissue Location: Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells (PubMed:10925275, PubMed:11046021, PubMed:10653850) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Interleukin-18 receptor 1, IL-18R-1, IL-18R1, CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, IL-1Rrp, IL1R-rp, CD218a, IL18R1, IL1RRP