IL1RN Antibody (C-term) [APR05755G]

IL1RN Antibody (C-term) [APR05755G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This IL1RN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-177 amino acids from the C-terminal region of human IL1RN.

Cellular Localisation: [Isoform 1]: Secreted. [Isoform 3]: Cytoplasm.

Molecular Weight: 20055

Clone: Polyclonal

Gene Name: IL1RN

Gene ID: 3557

Function: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Summary: Tissue Location: The intracellular form of IL1RN is predominantly expressed in epithelial cells

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: FC, IF, WB

Dilution: WB--1:4000 WB--1:1000 FC--1:10~50 IF--1:10~50

Synonyms: Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, ICIL-1RA, IL1 inhibitor, Anakinra, IL1RN, IL1F3, IL1RA