IL6 monoclonal Antibody | MB9296

IL6 monoclonal Antibody | MB9296 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: WB IHC ICC

Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200

Background: Interleukin-6, or IL-6, is a multifunctional protein, 212 amino acids in length, that plays critical roles in host defense, immune response and hematopoiesis. IL-6 is constitutively expressed by epidermal Langerhans cells and its expression is induced in stimulated keratinocytes. IL-6, IL-1β and TNFα act as endogenous pyrogens, regulating the fever response to bacterial invasion. The IL-6 receptor is a trimeric complex composed of an IL-6-specific α chain and a homodimer of the gp130 glycoprotein common to the IL-6, IL-11, CNTF, OSM and LIF receptors. Stimulation with IL-6 leads to gp130 homodimerization and the activation of associated kinases JAK1 and JAK2. Once activated, JAK1 and JAK2 phosphorylate Stat3, causing its nuclear translocation and transcription of Stat3-responsive genes. IL-6 has also been shown to activate the Ras/MAP kinase pathway, which regulates NFIL6 transcription.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: IL6 monoclonal Antibody detects endogenous levels of IL6 protein.

Molecular Weight: 24 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: IL-6, BSF-2, CDF, IFN-beta-2, IL6, IFNB2, Interleukin BSF 2, B cell differentiation factor, B cell stimulatory factor 2, B-cell stimulatory factor 2, BSF 2, BSF-2, BSF2, CDF, CTL differentiation factor, Hepatocyte stimulatory factor, HGF, HSF, Hybridoma growth factor, Hybridoma growth factor Interferon beta-2, IFN-beta-2, IFNB2, IL 6, IL-6, IL6, IL6, Interferon beta 2, Interferon beta-2, Interleukin 6, Interleukin 6 (interferon beta 2), Interleukin BSF 2, Interleukin-6,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProG affinity purified

Pathway: