IMD-0354 | B3210

IMD-0354 is a selective IKKβ inhibitor that blocks IκBα phosphorylation in NF-κB pathway. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM. It has been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.

IMD-0354 is a selective IKKβ inhibitor that blocks IκBα phosphorylation in NF-κB pathway. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM. It has been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.

B3210 | IMD-0354 DataSheet

Alternate Name/Synonyms: N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide,IMD0354

Appearance: Crystalline solid

Formulation:

CAS Number: 978-62-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₈ClF₆NO₂

Molecular Weight: 383.67

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >20 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective IKKβ inhibitor that blocks IκBα phosphorylation in NF-κB pathway

MDL Number: MFCD00218820

PubChem CID: 5081913

SMILES: C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O

InChi: InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)

InChi Key: CHILCFMQWMQVAL-UHFFFAOYSA-N