IMP-3 monoclonal Antibody | MB9303

IMP-3 monoclonal Antibody | MB9303 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: WB IHC ICC FC

Application Range: WB:1:1,000-1:2,000 ICC:1:50 IHC:1:50-1:200 FC:1:50-1:100

Background: Insulin like growth factor 2 mRNA binding proteins (IGF2BPs) bind RNA and influence RNA synthesis and metabolism. IGF2BP1, also known as coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein (CRD-BP), IMP1 or VICKZ1; IGF2BP2 (IMP2, VICKZ2, p62) ; and IGF2BP2 (IMP3, KOC1, VICKZ3) contain a unique combination of RNA recognition motifs and four hnRNP K homology domains. IGF2BP1 is abundant in embryonal tissues and is expressed in 81% of colon cancers, 73% of sarcomas and 58.5% of breast cancers. It recognizes c-Myc, IGF-II and t mRNAs, and H19 RNA, and plays a major role in proliferation of K-562 cells by an IGF-II-dependent mechanism. IGF2BP2 binds the 5' UTR of IGF-II mRNA and influences tumor cell growth, in which IGF2BP2 is associated with apoptosis induced by tretinoin. IGF2BP3 knockdown by RNA interference decreases levels of IGF-II protein without affecting IGF-II, c-Myc, or β Actin mRNA and H19 RNA levels. IGF2BP3 is a marker for carcinomas and high-grade dysplastic lesions of pancreatic ductal epithelium.

Storage & Stability: Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

Specificity: IMP-3 monoclonal Antibody detects endogenous levels of IMP-3 protein.

Molecular Weight: 62 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: IGF2 mRNA-binding protein 3, IMP-3, hKOC, IGF2BP3, IMP3, KOC1, VICKZ3, Cancer/testis antigen 98, CT98, DKFZp686F1078, hKOC, IF2B3, IGF II mRNA binding protein 3, IGF-II mRNA-binding protein 3, IGF2 mRNA binding protein 3, IGF2 mRNA-binding protein 3, IGF2BP3, IMP 3, IMP-3, Insulin like growth factor 2 mRNA binding protein 3, Insulin-like growth factor 2 mRNA-binding protein 3, KH domain containing protein overexpressed in cancer, KH domain-containing protein overexpressed in cancer, KOC 1, KOC1, VICKZ 3, VICKZ family member 3, VICKZ3,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: