IMP3 monoclonal Antibody | MB0144

IMP3 monoclonal Antibody | MB0144 | Gentaur UK, US & Europe Distribution

Host: Mouse IgG1

Reactivity: Human

Application: WB

Application Range: WB: 1:1000

Background: Imp3, also known as BRMS2, C15orf12 or MRPS4, is a 184 amino acid protein that contains one S4 RNA-binding domain and is the mammalian homolog of the yeast Imp3 protein. Localized to the nucleus, Imp3 exists as a component of a heterotrimeric complex consisting of MPP10, Imp3 and Imp4 and, in this complex, plays a key role in early cleavage events during pre-18S ribosomal processing. The gene encoding Imp3 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of IMP3 and does not cross-react with related proteins

Molecular Weight: Predicted band size:70KDa Observed band size:70KDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Insulin-like growth factor 2 mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer; hKOC; VICKZ family member 3; IGF2BP3; IMP3; KOC1; VICKZ3

Immunogen: Recombinant full length Human IMP3.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Tumor Angiogenesis,Contribution of ECM and Cytoskeletal Factors to EMT,