Description
IMPA1 polyclonal Antibody | BS8171 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC IF
Application Range: WB: 1:500~1:2000 IHC/IF: 1:50~1:200
Background: IMPA1, also known as Myo-inositol monophosphatase 1, is responsible for the procurement of inositol that is required for synthesis of phosphatidylinositol and polyphosphoinositides. IMPA1 exists as a homodimer and has been identified as the pharmacological target for lithium action in the brain. IMPA1 is the principal enzyme of the phosphatidyl inositol signaling pathway, and inhibition of inositol monophosphatase hydrolysis may underlie the anti-manic and anti-depressant actions of Li+. Studies indicate that a variation in the 277 codon coding region of the IMPA1 gene has not been observed in manic-depressive patients, therefore suggesting that polymorphisms or mutations in the noncoding regions of this gene may influence the lithium response in psychiatric patients.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IMPA1 polyclonal Antibody detects endogenous levels of IMPA1 protein.
Molecular Weight: ~ 30 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Inositol monophosphatase 1; IMP 1; IMPase 1; Inositol-1 (or 4) -monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; IMPA1; IMPA
Immunogen: Recombinant full length Human IMPA1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: