Gentaur

Influenza A NCP Monoclonal Antibody | 372-IAV254-100

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SKU:: 372-IAV254-100-GEN
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Description
Additional Information

Description

Influenza A NCP Monoclonal Antibody | 372-IAV254-100

Species Reactivity Virus

Published species Virus

Host/Isotype Mouse / IgG1, kappa

Class Monoclonal

Type Antibody

Clone 14C2

Immunogen M2 protein from A/WSN/33-infected CV1 cell lysate.

Conjugate Unconjugated

Form Liquid

Concentration 1 mg/mL

Purification Protein A

Storage buffer PBS with 1mg/mL BSA

Contains 0.05% sodium azide

Storage conditions -20° C, Avoid Freeze/Thaw Cycles

RRID AB_325043

Product Specific Information

MA1-082 detects the N-terminal of the influenza A virus M2 protein.

MA1-082 has been successfully used in Western blot, Immunofluorescence, immunocytochemistry and immunoprecipitation procedures. By Western blot, this antibody detects a ~15 kDa protein representing the M2 protein. MA1-082 has demonstrated the ability to immunoprecipitate M2 from [35s] cysteine-labeled WSN-infected cells.

MA1-082 has demonstrated the ability to restrict the replication of some strains of influenza A virus by binding to the extracellular N-Terminal domain.

The MA1-082 immunogen is M2 protein from A/WSN/33-infected CV1 cell lysate.

Target Information

Influenza A virus is an enveloped virus encoding 10 polypeptides. RNA segment 7 encodes for two proteins: M1 (matrix 1) and M2 (matrix 2). M1 protein is encoded by an mRNA that is colinear, while M2 protein is synthesized from spliced mRNA. M2 protein is a transmembrane protein composed of three Domains: 1) 24 residues representing the N-terminal region, 2) 19 hydro-phobic residues that serve as a membrane anchor, and 3) 54 residues near the C-terminal in the cytoplasmic domain. The M2 protein has been found to play a role in Influenza replication and assembly of virion particles. Further experimentation has demonstrated that this protein is an acid-activated ion channel for virus replication.

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