Integrin α3 (F531) polyclonal Antibody | BS3437

Integrin α3 (F531) polyclonal Antibody | BS3437 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Integrins are heterodimers composed of non-covalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. The Integrin α3 chain, also known as very late (activation) antigen 3 (VLA-3), very common antigen 2 (VCA-2), extracellular matrix receptor 1 (ECMR1) and galactoprotein b3 (GAPB3), undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with β1 to form an integrin that interacts with many extracellular-matrix proteins.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Integrin α3 (F531) polyclonal Antibody detects endogenous levels of Integrin α3 protein.

Molecular Weight: ~ 117 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Integrin alpha-3; CD49 antigen-like family member C; FRP-2; FRP2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD49c; ITGA3; MSK18

Immunogen: Synthetic peptide, corresponding to amino acids 500-550 of Human Integrin α3.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A